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At intoxicating doses, alcohol can decrease heart rate, lower blood pressure and respiration rate, and result in decreased reflex responses and slower reaction times. One of the most detrimental side effectst of heroin, is heroin addiction itself.
Heroin can cause infection of heart lining and valves.
Today Ecstasy is most often distributed at late-night parties called "raves", nightclubs, and rock concerts.
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Methadone
Side Effects 
Methadone is a (synthetic opiate) narcotic that when administered once a day, orally, in adequate doses, can usually suppress a heroin addict's craving and withdrawal for 24 hours. Patients are as physically dependent on methadone as they were to heroin or other opiates, such as Oxycotin or Vicodin.
Methadone side effects include but are not limited to:
- drowsiness
- lightheadedness
- weakness
- euphoria
- dry mouth
- urinary retention
- constipation
- slow or troubled breathing
Methadone side effects that are more rare include but are not limited to:
- allergic reactions
- skin rash
- hives
- itching
- headache
- dizziness
- impaired concentration
- sensation of drunkenness
- confusion
- depression
- blurred or double vision
- facial flushing
- sweating
- heart palpitation
- nausea
- vomiting
Methadone side effects that are more uncommon include but are not limited to:
- anaphylactic reactions
- hypotension causing weakness and fainting
- disorientation
- hallucinations
- unstable gait
- tremor
- muscle twitching
- myasthenia gravis
- kidney failure
- seizures
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